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供biovendor Uromodulin Human ELISA 欣博盛供
貨號(hào)：RD191163200R
名稱(chēng)：Uromodulin Human ELISA
規(guī)格：96 wells (1 kit)
產(chǎn)品描述：
尿調(diào)節(jié)蛋白（tamm-horsfall蛋白，umod）是一種大約85kDa的糖蛋白，產(chǎn)生于腎小管亨勒環(huán)的厚上肢和腎小管的早期遠(yuǎn)曲小管。它是一種跨膜蛋白，通過(guò)糖基磷酰肌醇（GPI）錨的蛋白水解酶分解分泌到尿液中。它屬于GPI家族。健康的人每天排泄數(shù)十毫克的尿調(diào)節(jié)蛋白，在尿液中形成最豐富的蛋白質(zhì)。尿調(diào)節(jié)蛋白通過(guò)與細(xì)胞因子相互作用調(diào)節(jié)細(xì)胞粘附和信號(hào)轉(zhuǎn)導(dǎo)，并抑制鈣晶體的聚集。通過(guò)減少草酸鈣沉淀，尿調(diào)節(jié)蛋白在腎結(jié)石形成方面起到保護(hù)作用，最近對(duì)易患腎結(jié)石的THP缺乏小鼠的研究表明。THP是一種宿主防御因子，可抵抗由大腸埃希菌、沙門(mén)葡萄球菌、奇異變形桿菌和肺炎克雷伯氏菌等泌尿病原體引起的尿路infect。尿調(diào)節(jié)蛋白與大腸桿菌1型菌毛結(jié)合，從而阻斷尿路上皮細(xì)胞的定植。tamm-horsfall蛋白與其他分子和細(xì)胞相互作用，包括IL-1、IL-2、TNF、IGG、中性粒細(xì)胞、淋巴細(xì)胞和單核細(xì)胞。尿調(diào)節(jié)蛋白與中性粒細(xì)胞的結(jié)合誘導(dǎo)IL-8的合成，刺激呼吸爆發(fā)和脫粒，刺激趨化和吞噬。最近，全基因組關(guān)聯(lián)研究發(fā)現(xiàn)尿調(diào)節(jié)蛋白是慢性腎病和hypertensi的危險(xiǎn)因素。尿調(diào)節(jié)蛋白基因突變與三種常染色體顯性腎小管間質(zhì)性腎病有關(guān)，如家族性青少年高尿酸血癥性腎?。‵Jhn）、髓質(zhì)囊性腎?。∕ckd2）和腎小球系統(tǒng)性腎?。℅CKd）。這些疾病的特點(diǎn)是青少年開(kāi)始高尿酸血癥，痛風(fēng)和進(jìn)行性腎衰竭。
特點(diǎn)：
European Union: for in vitro diagnostic use
Rest of the world: for research use only!
The total assay time is less than 3.5 hours
The kit measures uromodulin in serum, plasma (EDTA, citrate, heparin) and urine
Assay format is 96 wells
Standard is native protein based
Quality Controls are human serum based
Components of the kit are provided ready to use, concentrated or lyophilized
類(lèi)型：Sandwich ELISA, Biotin-labelled antibody
別名：Tamm-Horsfall urinary glycoprotein, THP, UMOD
物種：Human
樣本濃度：10 μl/well
校準(zhǔn)范圍：0.5–32 ng/ml
檢測(cè)限：0.12 ng/ml
應(yīng)用：Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate, Urine
運(yùn)輸：At ambient temperature. Upon receipt, store the product at the temperature recommended below
儲(chǔ)存/到期：tore the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
交叉反應(yīng)：
bovine Non-detectable
cat Non-detectable
dog Non-detectable
goat Non-detectable
hamster Non-detectable
horse Non-detectable
human Yes
pig Non-detectable
rabbit Non-detectable
rat Non-detectable
sheep Non-detectable
chicken Not tested
monkey Yes
mouse Non-detectable
試劑盒組成：
Antibody Coated Microtiter Strips 96 wells
Biotin Labelled Antibody Conc. (10x) 1.3 ml
Streptavidin-HRP Conjugate 13 ml
Master Standard 2 vials
Quality Control HIGH 2 vials
Quality Control LOW 2 vials
Dilution Buffer 20 ml
Biotin-Ab Diluent 13ml
Wash Solution Conc.(10x) 100 ml
Substrate Solution 13 ml
Stop Solution 13 ml
Product Data Sheet + Certificate of Analysis 1 pc
產(chǎn)品覆蓋以下研究領(lǐng)域, 主要提供ELISA試劑盒，重組蛋白及相關(guān)抗體
凋亡(Apoptosis)
糖尿病-胰島素、C-肽、胰島素原
(Diabetology - Insulin, C-Peptide, Proinsulin)
肌生長(zhǎng)調(diào)控
(Muscle Growth Control)
自身免疫 (Autoimmunity)
糖尿病-其他相關(guān)產(chǎn)品
(Diabetology - Other Relevant Products)
神經(jīng)組織標(biāo)志物
(Neural Tissue Markers)
血壓調(diào)節(jié)和NO代謝
(Blood Pressure Regulation And NO Metabolism)
能量代謝和體重調(diào)節(jié)
(Energy Metabolism And Body Weight Regulation)
腫瘤學(xué) (Oncology)
骨與軟骨代謝
(Bone And Cartilage Metabolism)
生長(zhǎng)hormone和生長(zhǎng)因子相關(guān)
(Growth Hormone And Factor-related Products)
氧化應(yīng)激 (Oxidative Stress)
心血管疾病
(Cardiovascular Disease)
免疫應(yīng)答、infect和炎癥反應(yīng)
(Immune Response, Infection And Inflammation)
胰調(diào)控分子
(Pancreatic Regulatory Molecules)
細(xì)胞粘連蛋白 (Cell Adhesion Proteins)
免疫學(xué) (Immunology)
腎臟疾病 (Renal Disease)
細(xì)胞因子、趨化因子及相關(guān)分子
(Cytokines And Chemokines And Related Molecules)
鐵代謝(Iron Metabolism)
生殖 (Reproduction)
糖尿病-自身免疫
(Diabetology – Autoimmunity)
脂蛋白代謝
(Lipoprotein Metabolism)
細(xì)胞表面蛋白
(Cell Surface Proteins (sCD) )
分泌型磷脂酶A2
(Secreted Phospholipases A2 show all)
血清學(xué) (Serology)
類(lèi)固醇hormone
(Steroid Hormones)
移植 (Transplantation)
動(dòng)物相關(guān)研究 (Animal Studies)
其他研究領(lǐng)域 (Others)
